Overview of Virtual Tumour

Technology

Inputs

  • Mouse and/or human PK
  • Control tumour growth data
  • PD data (xenografts, biomarkers)
  • Public or proprietary sources
Inputs

Cell-level model

  • End effect of drug on cell cycle modelled
  • Drug combination effects derive naturally from modelling approach
  • Agent based model tracks cell division and death
Cell-level Model

Tumour-level model

  • Volume of tumour derived from #cells
  • Simple tumour geography also accounted for
  • Multiple tumours per subject can be modelled (e.g. for human trials)
Tumour-level model

Outputs

  • Tumour dimensions over time (e.g. RECIST, WHO)
  • Outputs can be displayed in multiple formats to drive insights
Outputs