Physiomics. Rational Therapeutics

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Publications

Publications

• Using Predictive Mathematical Models to Optimise the Scheduling of Anti-Cancer Drugs David Orrell and Eric Fernandez, Innovations in Pharmaceutical Technology, June 2010

• Using mammalian cell cycle simulation to interpret differential kinase inhibition in anti-tumour pharmaceutical development C Chassagnole, R.C. Jackson, N. Hussain, L. Bashir, C Derow, J. Savin and D.A. Fell, BioSystems Volume 83, Issues 2-3, February-March 2006, pages 91-97. Reprint on request

Posters

• The application of three-dimensional cell cultures in combination with the Virtual Tumor™ for designing optimal drug dosing schedules Frances Brightman, Eric Fernandez, David Orrell, David Fell, Christophe Chassagnole, EORTC-AACR Meeting, San Francisco, CA, USA, 12th - 16th November 2011
• Predicting the effect of combination schedules on xenograft tumor using the Virtual Tumor David Orrell, Eric Fernandez, Damien Cronier, Lawrence M. Gelbert, David A. Fell, Dinesh De Alwis and Christophe Chassagnole AACR 102th Annual Meeting 2011, Orlando, FL, 2-6 April 2011
• Modeling the sequence-sensitive gemcitabine-docetaxel combination using the Virtual Tumor Eric Fernandez, David Orrell, Caroline Mignard, Zina Koob, Damien France, Nicolas Hoffmann, Francis Bichat, David Fell, Christophe Chassagnole AACR 102th Annual Meeting 2011, Orlando, FL, 2-6 April 2011
• Computer modelling of Nocodazole exposure on cell cultures in vitro E Fernandez, G Johnson, D Orrell, C Snell, DA Fell, SH Doak and C Chassagnole AACR-EORTC-NCI \"Molecular Targets and Cancer Therapeutics\", Boston, MA, 16 November 2009.
• Chronotherapy: Seliciclib dosing schedules determined using a detailed computational cancer model AR Hardy, E Fernandez, C Snell, D Orrell, DA Fell and C Chassagnole AACR 100th Annual Meeting 2009, Denver, CO, 18-22 April 2009.
• Optimal cancer chronotherapeutic schedules of Seliciclib revealed by a systems biology approach E Fernandez, A Hardy, D Orrell, L Ramsell, DA Fell and C Chassagnole AACR 2008, San Diego, CA, 12-16 April 2008.
• Systems biology analysis of CYC116, a novel aurora kinase inhibitor C Chassagnole, E Fernandez, F Scaërou, C Snell, D Zheleva, DM Glover, RC Jackson, DA Fell AACR 2008, San Diego, CA, 12-16 April 2008.
• Modelling DNA Damage-Induced Apoptosis A R Hardy, D Orrell, C M Snell, C Chassagnole, G Morris and D A Fell ICSB 2007, Long Beach, CA, 1-6 October 2007.
• Virtual Tumour Modelling The Effect of Aurora Kinase Inhibitors on the Cell Cycle C Chassagnole, C M Snell, A R Hardy, A Finney, E Fernandez and D A Fell EBI, Cambridge, UK, 11-13 March 2007.

Presentations

• Cancer Modeling and Drug Schedule Optimization Dr Christophe Chassagnole, COO EPIC 2010, London, UK, 26 June 2010.
• Making better Cancer Therapies with Modelling Dr. Christophe Chassagnole, COO EPIC 2009, London, UK, 25 June 2009.
• Systems Biology for Cancer Drug Development Dr. Christophe Chassagnole, COO BIO-Europe 2008, Mannheim/Heidelberg, Germany, 17-19 November 2008.
• Optimal cancer chronotherapeutics schedules using a Systems Biology approach - Chronotherapeutics of Seliciclib Dr. Christophe Chassagnole, COO Beyond Genome Conference 2008, San Francisco, CA, 8-11 June 2008.
• Drug Discovery and the New Biology Pr David A Fell, CSO Biotuesday – Milton Park, Abingdon, UK, 20 February 2007.